,+&ơ11*
751*,+&63+0

+81+7+7+<

1*+,ầ1&8&+,77ẩ&+;ẩ&1+

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&$
/ẩ',3&ẩ
(HOUTTUYNIA CORDATA)
7+8+ẩ,7,481*1$0
- ơ11*

/81917+&6
+ẽ$+&

1*,+
1*'1.+2$+&
GS.TS ơ2+ễ1*&1*

j1

ng, nP
8


/Ӡ,&$0Ĉ2$1

7{L [LQ FDP ÿRDQ ÿk\ Oj F{QJ WUuQ

ULrQJW{L&iFV͙OL͏XV͵GͭQJSKkQ

ÿmF{QJE͙WKHRÿ~QJTX\ÿ͓QK&iFN
TX̫QJKLrQFͱXWURQ

W͹WuPKL͋XSKkQWtFKP͡WFiFKWUX

WL͍Q FͯD 9L͏W 1DP &iF N͇W TX̫ Qj\
QJKLrQFͱXQjRNKiF

7iFJL̫OX̵QY

+XǤQK7K͓7Kͯ\

i


/Ӡ
,&Ҧ0Ѫ1

9ͣLOzQJNtQKWU͕QJYjEL͇W˯QVkX

ÿ͇QWRjQWK͋FiFWK̯\F{WURQJNKRD

NL͇Q WKͱF TXêEiXĈ̿F EL͏W HP [LQJ

QJ˱ͥL WK̯\ ĈjR
ÿm+QJ
WU͹F&˱ͥQJ
WL͇S

và FK͑
em sinh viên
E̫R FK

Ĉ̿QJ7K͓1J͕F+̩QKÿmJL~SÿͩHP
KRjQWKjQKEjLOX̵QY

;LQFKkQWKjQKF̫P˯Q%DQJLiPKL͏

7U˱ͥQJ Ĉ+63 Ĉj 1̽QJ ÿm W̩R ÿL͉X NL͏
WUuQKK͕FW̵S
YjQJKLrQFͱXÿ͉WjL

;LQFKkQWKjQKF̫P˯Q
các WK̯\F{JLiRFiQE͡S

+yDK͕FNKRD6LQK7U˱ͥQJĈ+63Ĉj

JL~SÿͩW̩RÿL͉XNL͏QFKRHPWURQJ

&X͙LFQJHP[LQJ͵LOͥLF̫P˯
QW̵SWK͋OͣS++&
-.ÿmJL~S

ÿ͡QJYLrQHPWURQJTXiWUuQKK͕FW̵S
+ӑFYLrQ

+8ǣ1+7+ӎ7+Ӫ<

ii



0&/&
/,&$02$1
.............................................................................................. i
/,&01
................................................................................................... ii
0&/&
........................................................................................................ iii
'$1+0&&ẩ&&+9,777
.............................................................. vi
'$1+0&&ẩ&%1*%,8
................................................................... vii
'$1+0&&ẩ&+ẻ1+1+
.................................................................... viii
08
........................................................................................................... 1
/ậ'2&+17ơ,
............................................................................... 1
0&ậ&+1*+,ầ1&8
...................................................................... 2
,71*9ơ3+09,1*+,ầ1&8
.......................................... 2
LWQJQJKLrQFX
.......................................................................... 2
3KPYLQJKLrQFX
............................................................................. 2
3+1*3+ẩ31*+,ầ1&8
............................................................. 2
1JKLrQFXOtWKX\W

............................................................................. 2
1JKLrQFXWKFQJKLP
...................................................................... 2

ộ1*+$.+2$
+&9ơ7+&7,1&$7ơ,
........................ 3
ộQJKDNKRDKF
................................................................................. 3
ộQJKDWKFWLQ
.................................................................................. 3
6. BCC CӪA LUҰ19Ă1
...................................................................... 3
&+ѬѪ1*
. 7Ә1*48$17¬,/,ӊ8
........................................................... 5
0Ð7Ҧ7+Ӵ&9Ұ7
........................................................................... 5
7rQJӑL
........................................................................................... 5
9ӏWUtSKkQORҥL
............................................................................... 5
0{WҧFk\
....................................................................................... 5
3KkQEӕVLQKWKiL
........................................................................... 6
7+¬1+3+Ҫ1+Ï$+Ӑ&
VӄLÁ DIӂP CÁ ................................... 7
iii



7LQKGҫX
.......................................................................................... 7
1.2.2. Flavonoid ....................................................................................... 7
1.2.3. Alkaloid ......................................................................................... 9
1.'үQFKҩWWKѫPÿѫQJLҧQ
............................................................... 10
7KjQKSKҫQNKiF
.......................................................................... 10
7È&'Ө1*'ѬӦ&/é&Ð1*'Ө1*
cӪa lá diӂp cá ................. 10
7iFGөQJGѭӧFOê
......................................................................... 10
&{QJGөQJ
±Cách dùng .............................................................. 13

1.4. TÌNH HèNH 1*+,ầ1&87521*1&9ơ7
*,,9&ặ<',3&ẩ
.......................................................................... 15

7uQKKuQKQJKLrQFXQJRjL
................................................ 15
7uQKKuQKQJKLrQFXWU
RQJQF
................................................. 16

076&+3+075ầ17+75
.................................. 17

&+1*

. 1*8<ầ1/,89ơ3+1*3+ẩ31*+
1&8
......... 20

1*8<ầ1/,8+ẽ$&+79ơ7+,7
.......... 20
1JX\rQOLX
.................................................................................. 20

+yDFKWGQJFYjWKLW
.................................... 20
3+1*3+ẩ31*+,ầ1&8
....................................................... 21
3KQJSKiS[iF
QKFiFWK{QJVKyDOờ
................................. 21

3KQJSKiSFKLWPXWKF
................................................. 24

3KQJSKiSSKkQWtFKYj
FDFiF
GFKFKLW
................................................................................................ 26

3KQJSKiSWiFKYjWLQKFK
.............................................. 26

3KQJSKiS[iFQKFXWU
................. 27


3KQJSKiSWKKRWWtQKV
............................................ 27
61*+,ầ1&87+&1*+,0
........................................... 29
6,8&+&ẩ&&$2&+,7
................................................. 30

3+ặ1/3&+77521*&$2&+,7
............. 31
iv


&+ѬѪ1*
. .ӂ748Ҧ9¬7+Ҧ2/8Ұ1
.................................................. 33

.ӂ748Ҧ;È&Ĉӎ1+&È&7+Ð1*6Ӕ
.......................... 33
ĈӝҭP
........................................................................................... 33
+jPOѭӧQJWUR
.............................................................................. 34
+jPOѭӧQJNLPORҥL
..................................................................... 34

D;iFÿӏQKKjPOѭӧQJPӝWVӕNLPO
LQһQJ
........................................ 34


.ӂ748Ҧ7+Ӱ+2Ҥ77Ë1+6,1++Ӑ&
. ........................................ 35
 .ӂ7 48Ҧ ;È& Ĉӎ1+ 7+¬1+ 3+Ҫ1
&È&'ӎ&+&+,ӂ7%Ҵ1*3+ѬѪ1*3+È3
GC-MS .............................. 37

7KjQKSKҫQKyDKӑFWURQJGӏ
-hexan ............................ 37

7KjQKSKҫQKyDKӑFWURQJGӏ
....................... 39

7KjQKSKҫQKyDKӑFWURQJGӏ
..................... 42

7KjQKSKҫQKyDKӑFWURQJGӏ
............................ 43

 .ӂ7 48Ҧ 3+Ỉ1 /Ұ3 &È& &+Ҩ7 752
'ӎ&+&+,ӂ7&+/252)250
.................................................................. 45
.ӂ7/8Ұ19¬.,ӂ11*+ӎ
......................................................................... 55
.ӂ7/8Ұ1
.............................................................................................. 55
.,ӂ11*+ӎ
............................................................................................ 56
'$1+0Ө&7¬,/,ӊ87+$0.+Ҧ2
........................................................ 57


v


'$1+0Ө&&È&
&+Ӳ9,ӂ77Ҳ7
D

: Doublet (NMR)

J(Hz)

+ҵQJVӕWѭѫQJWiF105


Rf

: Retention factor

s

: Singlet (NMR)

ppm

: Parts per million

į

ĈӝFKX\ӇQGӏFKKyDKӑF1


CD3OD

: Methanol- D

CHCl3

: Chloroform

D

: Dichlomethane

DMSO

: Dimethyl sunfoxide

DEPT

: Distortionless enhancement by polarisation transfer

EtOAc

: Ethyl acetate

EtOH

: Ethanol

GC-MS


: Gas chromatography-Mass spectrometry

HMBC

: Heteronuclear Multiple Bond Correlation

HSQC

: Heteronuclear Single Quantum Corelation

MeOH

: Methanol

Me

: Methyl

NMR

: Nuclear magnetic resonance

SRB

: Sulforhodamine B

UV

: Ultraviolet


HC

7rQKӧSFKҩWSKkQOұSÿѭӧ

vi


'$1+0Ө&&È&%Ҧ1*%,ӆ8
6ӕ
KLӋX

7rQEҧQJ

Trang

1.1

Vӏtrí phân loҥ
i chi Houttuynia trong giӟi thӵc vұ
t

1.2

0ӝWVӕFKӃSKҭPFKӭD'LӃSFiWUrQW
17

3.1

.ӃWTXҧ[iFÿӏQKÿӝҭPFӫDOiGLӃS
33


3.2

.ӃWTXҧ[iFÿӏQKÿӝҭPFӫDQJX\rQO
33

3.3

KӃ
t quҧ[iFÿ
ӏ
QKKjPOѭ
ӧng tro trong lá diӃ
p cá

3.4

.ӃWTXҧ[iFÿӏQKKjPOѭӧQJNLPORҥL
35

3.5

.ӃWTXҧWKӱKRҥWWtQKFKӕQJR[LKyD
36

3.6

7KjQKSKҫQKyDKӑFWURQJGӏFKFKLӃW
-KH[DQOiGLӃSFi
37


3.7

Thành SKҫQKyDKӑFWURQJGӏFKFKLӃW
chloroform OiGLӃSFi42

3.8

7KjQKSKҫQKyDKӑFWURQJGӏFKFKLӃW
etylaxetat OiGLӃSFi 44

3.9

7KjQKSKҫQKyDKӑFWURQJGӏFKFKLӃW
metanol OiGLӃSFi 40

3.10

6ӕOLӋXSKә105FӫDKӧSFKҩW+&Yj
53

vii

5

34


'$1+0Ө&&È&+Ỵ1+Ҧ1+
6ӕKLӋX


Tên hình

Trang

1.1

Cây diӃ
p cá

6

1.2

Hoa diӃ
p cá

6

2.1

'ѭ
ӧc liӋ
u lá DiӃ
p cá khô

20

2.2


6ѫÿ
ӗthӵc nghiӋ
m

29

2.3

6ѫÿӗFKLӃWPүXOiGLӃSFi
30

3.1

6ҳFNêÿӗ*&
-06FӫDGӏFKFKLӃWQ
-hexan trong OiGLӃSFi
37

3.2

6ҳFNêÿӗ*&
-06FӫDGӏFKFKLӃW
clorofom trong OiGLӃSFi
40

3.3

6ҳFNêÿӗ*&
-06FӫDGӏFKFKLӃW
etyaxetat trong OiGLӃS

cá
42

3.4

6ҳFNêÿӗ*&
-06FӫDGӏFKFKLӃW
metanol trong OiGLӃSFi
44

3.5

&ӝWVҳFNê

43

3.6

Sҳ
c ký bҧ
n mӓ
ng cӫa HC2

45

3.7a

Phә1H-NMR cӫ
a hӧp chҩ
t HC2


48

3.7b

Phә1H-NMR cӫ
a hӧp chҩ
t HC2

49

3.7c

Phә1H-NMR cӫ
a hӧp chҩ
t HC2

50

3.8a

Phә13C-NMR cӫ
a hӧp chҩ
t HC2

51

3.8b

Phә13C-NMR cӫ

a hӧp chҩ
t HC2

52

3.8c

Phә13C-NMR cӫ
a hӧp chҩ
t HC2

52

3.9

Cҩ
u trúc hóa hӑc cӫa hӧp chҩ
t HC2

53

viii


0ӢĈҪ8
1. /Ë'2&+Ӑ1Ĉӄ7¬,

9ҩQÿӅNӃWKӧS\KӑFFәWUX\ӅQYӟL\
D \KӑFF


WUX\ӅQOj[XKѭӟQJFKXQJFӫDWKӡLÿҥL

QѭӟFNK{QJFKӍOjQѭӟFFyEӅGj\WUX\Ӆ

QJKuQQăPQD\PjWKӵFVӵOjQѭӟFFyW
YjÿmÿҥWÿ

QKѭQ
g thành cơng EDQÿҫXWURQJYҩQÿӅNӃWKӧS\

1KӳQJWKjQKWӵXÿyÿmJySSKҫQWtFKFӵF

KLӋXTXҧÿLӅXWUӏÿӕLYӟLPӝWVӕEӋQKP

<KӑFFәWUX\ӅQFҫQÿѭӧFKLӋQÿҥLKy
FyQJX\FѫWUӣWK

ÿӗFәWKHRFKLӅXGjLFӫDWKӡLJLDQPj

FӫD[m KӝLKLӋQÿҥL+LӋQÿҥL KyDOjF

SKiSQJKLrQFӭXNKRDKӑF
-NӻWKXұWKLӋQÿҥLÿӇKLӇXY
KFiFFѫVӣ

KӑFFӫDQJX\rQ WKX\ӃWYjSKѭѫQJ

FiFEjLWKXӕFYjÿһFELӋWOjFiFFKҩWF

7X\ QKLrQKLӋQQD\FiFQJX\rQOLӋX


QKLӅX

Yj QKLӅX FKӃ SKҭP Wӯ GѭӧF OLӋX FzQ

KѭӣQJUҩWQJKLrPWUӑQJÿӃQVӭFNKӓHFӫD

FӫDPӑLQJѭӡLNKLVӱGөQJFiFFKӃSKҭP

OұSÿѭӧFFiFWKj
QKSKҫQFKtQKWURQJGѭӧFOLӋXYӟ

FKRF{QJWiFNLӇPQJKLӋPWLrXFKXҭQK

1JRjL UD Wӯ FiF FKҩW WLQK NKLӃW
LӋP
in Qj\ F

vitro, in vivo
QKҵPFKӭQJPLQKWiFGөQJYjWuPU

7URQJTXiWUuQKQJKLrQFӭXPӝWVӕFk

Fk\'LӃSFiQJRjLYLӋFVӱGөQJOjPUDX
g

UҩWQKLӅXÿӇÿLӅXWUӏEӋQKWUƭPөQQKӑ
'ѭӧFOLӋXQj\FNJQ

NKҭXVDQJ1KұWYjÿѭӧFÿѭDYjR'Ĉ91

7UXQJ4XӕF
).

1


9LӋF
VӱGөQJ
OiGLӃSFi
KLӋQQD\YүQFKӍWKHRNLQK
LӋF

WuPKLӇXWKjQKSKҫQKyDKӑFYjFDRKѫQ

FөWKӇFӫD
OiGLӃSFi
OjPӝWYLӋFOjPKӃWVӭFFҫQWKL

GөQJQJXӗQQJX\rQOLӋXVҹQFyӣ9LӋW1D
ÿLӅX

NLӋQFKRSKpSFӫDOXұQYăQWKҥFVƭW{L
1JKLrQFͱX
FKL͇WWiFK[

WKjQK SK̯Q
SKkQ
KyD K͕F
O̵S
WURQJ

Yj
FK̭W
G͓FK

FͯD
Oi
FKL͇W
GL͇S

WKXFi
KiL W

4X̫QJ1DP
±

Ĉj1̽QJ
´OjPÿӅWjLOXұQYăQWKҥFVƭ
0Ө&ĈË&+1*+,Ç1&Ӭ8
- Nghiên cӭu chiӃ
WWiFK[iFÿ
ӏ
nh thành phҫ
n hóa hӑc cӫ
a mӝt sӕdӏ
ch chiӃ
t lá
diӃ
p cá.
- 7KăPGzKR
ҥ

t tính sinh h
c ca cỏc d
ch chi
t lỏ di
p cỏ.

- 3KkQOSPWVKSFKWKRiKFW
[iF

QKFXWU~FKRiKFFDFK~QJJySS

KFYWKjQKSKQKyDKFQkQJFDRJLi
WKFYWQj\W
WLQ
3,71*9ơ3+09,1*+,ầ1&8
3.1.
LW
ng nghiên cӭu
/iGLӃS

FiÿѭӧFWKXKiLWҥL4XҧQJ1DP
-Ĉj1ҹQJ
3.2. Phҥ
m vi nghiên cӭu
- Thành phҫ
n hóa hӑ
c cӫa mӝt sӕdӏ
ch chiӃ
t lá diӃ
p cá.


- 3KkQÿRҥQGӏFKFKLӃWGѭӧFOLӋXOiGL

- &iFKӧSFKҩWSKkQOұSWӯGӏFKFKLӃW
.
3+ѬѪ
1*3+È31*+,Ç1&Ӭ8
4.1. Nghiên cӭu lí thuyӃ
t

- Thu thұ
p, tә
ng hӧp, phân tích các tài liӋ
XWѭOL
Ӌ
XWURQJYjQJRjL
ӟc vӅÿ
һ
c
ÿL
Ӈ
m hình thái thӵc vұ
t, thành phҫ
n hóa hӑc, tác dөQJGѭ
ӧc lý cӫa cây diӃ
p cá.

- Tә
ng hӧp tài liӋ
u vӅSKѭѫQJSKiSQJKLrQF

ӭu chiӃ
WWiFKYj[iFÿ
ӏ
nh các hӧp
chҩ
t thiên nhiên.
4.2. Nghiên cӭu thӵc nghiӋ
m
- 3KѭѫQJSKiSO
ҩ
y mү
u, thu hái và xӱlý mү
u.

2


- 3KѭѫQJSKiS
trӑQJOѭ
ӧQJÿ
Ӈ[iFÿ
ӏ
nh các thơng sӕhóa lí.
- 3KѭѫQJSKiSSKkQK
ӫy mү
u phân tích (tro hoá mү
u).

- 3KѭѫQJSKiSFKL
Ӄ

t: ngâm chiӃ
t WURQJGXQJP{L0H2+VD
Ӄ
t lҥ
i trong
FiFGXQJP{LFyÿ
ӝphân cӵFWăQJG
ҫ
n: n-hexan, clorofom, ethyl acetate, metanol.
- 3KѭѫQJSKiSY
ұ
t lý: quang phәhҩ
p thөnguyên tӱ(AAS) ÿ
Ӈ[iFÿ
ӏ
nh hàm
Oѭ
ӧng các kim loҥ
i nһ
ng; sҳ
c ký khí ghép phәkhӕi (GC-MS) nhҵ
m [iFÿ
ӏ
nh thành

phҫ
Q
ӏ
nh ÿ
danh các cҩ

u tӱtrong mӛ
i dӏ
ch chiӃ
W FiF SKѭѫQJ
әIR, 1H- SKiS
NMR, 13C-NMR, DEPT, 06[iFÿ
ӏ
nh cҩ
u trúc cӫa cҩ
u tӱtinh khiӃ
t phân lұ
Sÿѭ
ӧc.

- PKѭѫQJSKiSWK
ӱhoҥ
t tính sinh hӑc: SKѭѫQJSKiSWK{QJTX
ҧ
n ӭng bao
vây gӕc tӵdo(DPPH).

é1*+Ƭ$.+2$+Ӑ&9¬7+Ӵ&7,ӈ1&Ӫ$Ĉӄ
éQJKƭDNKRDK
ӑc
- Cung cҩ
p nhӳng thơng tin khoa hӑc vӅquy trình chiӃ
WWiFK[iFÿ
ӏ
nh thành
phҫ

n hóa hӑ
c, hoҥ
t tính sinh hӑ
c cӫa mӝt sӕdӏ
ch chiӃ
t lá diӃ
p cá, góp phҫ
n khai
thác sӱdөng hiӋ
u quҧcây thuӕc cәtruyӅ
n này.
- Tҥ
o tiӅ
Qÿ
Ӆcho nhӳng nghiên cӭXVkXKѫQY
Ӆcây diӃ
p cá ӣViӋ
t Nam.
éQJKƭDWK
ӵc tiӉ
n
- Sӱdөng cây diӃ
p cá chӳa bӋ
nh mӝt cách khoa hӑc, khơng chӍhҥ
n chӃtrong
y hӑc cәtruyӅ
n mà cịn có thӇmӣrӝng nghiên cӭu nhiӅ
XKѫQÿ
ӇchӃtҥ
o các dҥ

ng
thuӕ
c trong y hӑ
c hiӋ
Qÿ
ҥ
i.
- Giҧ
i thích mӝt cách khoa hӑc mӝt sӕcông dө
ng chӳa bӋ
nh theo kinh nghiӋ
m
dân gian cӫa cây diӃ
p cá.
- Mӣrӝng phҥ
m vi khai thác cây diӃ
p cá, khơng chӍcó lá mà các bӝphұ
n khác
cӫDFk\FNJQJ
có thӇcó tác dө
QJGѭ
ӧc lý.
6. BӔCӨC CӪA LUҰ19Ă1

/XұQYăQEDRJӗP
59 trang, 12 EҧQJ
18 hình, 26 WjLOLӋXWKDPNKҧ
&ҩXWU~FOXұQYăQQKѭVDX
MӣÿҫX
4 trang)

&KѭѫQJ
7әQJTXDQ
(15 trang)

&KѭѫQJ
. NJX\rQOLӋXYjSKѭѫQJSKiSQJKLr
(13 trang)

3


&KѭѫQJ
3.ӃWTXҧYjWKҧROXұQ
(22 trang)
.ӃWOXұQYjNLӃQQJKӏ
trang)
7jLOLӋXWKDPNKҧR
trang)
3KөOөF
(14 trang)

4


&+ѬѪ1*
7Ә1*48$1
7¬,/,ӊ8
1.1. MƠ TҦTHӴC VҰT
1.1.1. Tên gӑi


'LӃSFiKD\FzQFyWrQNKiF&k\OiJ

JLҩ\Fi5DXGLӃS

WKҧR74
5kXWUҫX+¶0{QJ
&KӡPӡPt

+HDUWOHDI+RXWWX\QLD+HUE$QK
OjGѭ

7rQNKRDKӑFOj
Houttuynia cordata 7KXQEKӑ/i*LҩS6DX
DFHDHÿѭӧF

ÿӇ W{Q YLQK 0DUWHHQ
±

+RXWWX\Q
WKҫ\ WKXӕF

Yj Q
/DQFKX\rQYӅ5rXYj4X\ӃWWKӵFYұW>
8].
1.1.2. Vӏtrí phân loҥ
i

Chi Houttuynia WKXӝFKӑ6DXUXUDFHDH9ӏWUtF
LWURQJJLӟLWKӵ
6].


9ӏWUt
SKkQORҥLFKL+RXWWX\QLDWURQJJLӟ

%̫QJ
19͓WUtSKkQOR̩LFKL+RXWWX\
*LӟL

Plantae

Ngành

Magnoliophyta

/ӟS

Magnoliopsida

%ӝ

Piperales

+ӑ

Saururaceae

Chi

Houttuynia


1.1.3. Mơ tҧcây

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tUҳQJ WU{QJ WRjQ Eӝ EӅ QJRjL FӫD FөP E
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-8.

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iL[RDQQKҹQ0DTXҧ
±10.

5


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dLӃ
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Hình 1.1&k\GL͇SFi Hình 1.2. Hoa dL͇SFi
1.1.4. 3KkQEӕVLQKWKiL

Chi Houttuynia FKӍFyPӝWORjL'LӃSFiSKkQ

FұQQKLӋWÿӟL
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Oi

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ÿӃQPӭFҧQKKѭӣQJÿӃQFiFORjLFk\NKiF
1].

7KX KiL FjQK Oi TXDQK QăP WKѭӡQJ G
dùQJGҫQ

6


1.2.
7+ơ1+3+1+ẽ$+&
VL DIP C

7KjQKSKQFK\XFD'LSFiJPWL
EpRô
1.2.1 Tinh d
u

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FHWRQ QK
-QRQ\O
PHWK\O
FHWRQ
\ Oj
Q
FKW
k
OjP FKR- 'LS

decanal, 1-GRGHFDQDO Oj QKӳQJ FKҩW NK{QJ NKiQ
NKXҭQOj
-oxododecanal.
1KyPWHUSHQEDRJӗPFiFFKҩW
Į-pinen, camphen, myrcen, limonen, linalol,

bornyl acetat, geraniol. Ngoài ra tinh GҫX FzQ FKӭD DFLG FDSU
benzamid,acid hexadecanoic, acid decanoic, acid palmitic, acid linoleic, acid oleic,
acid stearic, aldehyd capric, acid chlorogenic, lipid và vitamin K [1].
1.2.2. Flavonoid
- quercetin-3-O-beta-D-galactosid-7-O-beta-D-glucosid
- kaempferol-3-O-alpha-L-rhamnopyranosyl-(1-6)-beta-D-glucopyranosid
- quercitrin
- quercetin-3-O- ȕ-D-galactopyranosid (hyperin)
- quercetin-3-O-alpha-L-rhamnopyranosyl-7-O-beta-D-glucopyranosid
- phloretin-¶
-O-ȕ-D-glucopyranosid (phloridzin)
- quercetin-3-O-Į-L-arabinofuranosid (avicularin)
- isoquercitrin


&iF IODYRQRLG ÿiQJ FK~ ê WURQJ GL

LVRTXHUFLWULQK\SHULQYjSKORUHWLQ
jQKӳQJKӧS

FyWiFGөQJNKiQJXQJWKѭYjWiFGөQJ

WUӏQKӳQJEӋQKOLrQTXDQÿӃQJӕFWӵGR
15] , [16], [18].

7


OH

OH

HO
O

HO

O

HO

OH

HO


OH

O

OH

O

OH

OH

O

OH

O

O

OH
OH

HO

O

O

OH


HO

OH

O

HO

OH

Quercetin

Quercitrin

Hyperin

CTPT: C15H10O7

CTPT: C21H20O11

CTPT: C21H20O12

KLPT: 302.24

KLPT: 448.38

KLPT: 464.38

OH

O

HO

OH

OH

O

O
OH

O

OH

O

HO

OH

OH
OH

OH

Isoquercitrin


Phloretin

CTPT: C21H20O12

CTPT: C15H14O5

KLPT: 464.38

KLPT: 274

8

OH


Ngồi ra diӃSFi1KұWFzQFKӭD
afzelin [23]

OH
HO

O
O
OH

O
HO

O


HO

OH
OH

ĈӕLYӟL'LӃSFiPӑFӣ9LӋW
NamFyWjLOLӋXF{QJEӕW

LVRTXHUFLWULQ QKѭQJ NK{QJ Fy TXHUFLWU
(0,2%), mà khơng có isoquercitrin [7], [10].
1.2.3. Alkaloid

0ӝW Vӕ DONDORLG Fy KRҥW WtQK VLQK K

piperolactam A, norcepharadion B, cepharadion, spleQGLGLQ ÿѭӧF WuP

GӏFKFKLӃWPHWKDQROFӫDFk\'LӃSFiF

QJѭӡL$
-549, Sk-MEL-2, XF-489, HCT-15) [19@1JRjLUDFzQFy
dioxo aporphin [20].

O

O

O

H


O
N

O

O
O

O

H

N

H
H

O

N
O

H

O

Aristolactam A

Aristolactam B


9

Norcepharadion B


O

N

H

H

N
O

H

O

H

O

O

O

O
O


O

H

H

O
H

N

O

O

cepharadion A

cepharadion B

plendidin

1.2.4. Dү
n chҩ
WWKѫPÿѫQJL
ҧ
n
- Chlorogenic methyl ester
- (E)-4-Hydroxy-4->¶EHWD
-D-glucopyranosyloxy) butyliden]-3, 5,

5-trimethyl-2-cyclohexan-1-on
- 2-(3,4-dihydroxyphenyl) ethyl-beta-D-glucopyranosid
- p-hydroxyphenethyl-beta-D-glucosid
- 4-(beta-D-glucopyranosyloxy)-3-hydroxy-Benzoic acid
1.2.5. Thành phҫ
n khác

7KjQK SKҫQ WURQJ
nѭӟF
Fk\

GLӃS Fi
SURWLG
FzQ Fy


FHOOXORVHGүQ[XҩWNK{QJSURWHLQ

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