Applications of nanocurcumin in cancer treatment
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NANO
CURCUMIN
TEAM
5
Nguyen Thi Thanh Ngan
Nguyen Bảo Ngoc
Le Thi Thanh Trang
CONTENTS
1
Introduction
2
Properties
3
Applications of
cancer
treatment
Why use nanosized of
curcumin ?
What is curcumin ?
Sources : the rhizomes of Curcuma longa
IUPAC’s name : (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta1,6-diene-3,5-dione
It has been widely used as coloring agent and spice in food, drugs,
and cosmetics for centuries.
Structure
s
Properties
P
Physical
B
Biologycal activities
of curcumin
Orange-yellow
crystalline powder
Insoluble in water
Very soluble
in ethanol, acetic acid
Physical
properties
183 °C
Biologycal
activities of
curcumin
Anti-inflammatory.
Antioxidant
Antiproliferative
Antiangiogenic
activities
activities
Molecular targets
of curcumin
Step 1 : PLGA is sprayed into
supercritical CO2, in which
nanoparticles are formed by
ultrasonic vibrations
Step 2 : PLGA-curcumin
nanocapsules were obtained with
an average size of 63 nm and 38%
loaded, under ultrasonic power of
210 W, and with an average size
of 40 nm and 36% of load, at an
ultrasound capacity of 350 W
>
@
Nanotechnolog
y
Application of
cancer
treatment
800 reports have been
published
demonstrating the
anticancer potential of
curcumin
GASTRIC CANCER
THE NUMBERS
2nd
8th
69/100K
***
IN THE WORLD
IN THE USA
IN JAPAN
IN VIETNAM
SYMPTOMS
EXPERIMENTS
Products
Products
References
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