NOVEL THERAPEUTIC
CONCEPTS IN
TARGETING GLIOMA

Edited by Faris Farassati











Novel Therapeutic Concepts in Targeting Glioma
Edited by Faris Farassati


Published by InTech
Janeza Trdine 9, 51000 Rijeka, Croatia

Copyright © 2012 InTech
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First published April, 2012
Printed in Croatia

A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from


Novel Therapeutic Concepts in Targeting Glioma, Edited by Faris Farassati
p. cm.
ISBN 978-953-51-0491-9









Contents

Preface IX
Part 1 Surgical Therapy of Glioma 1
Chapter 1 Innovative Surgical Management of Glioma 3
Dave Seecharan, Faris Farassati
and Ania Pollack
Part 2 EGFR and Glioma Therapy 25
Chapter 2 Advances in the Development of EGFR Targeted
Therapies for the Treatment of Glioblastoma 27
Terrance Johns
Chapter 3 Future Perspectives of Enhancing
the Therapeutic Efficacy of Epidermal Growth
Factor Receptor Inhibition in Malignant Gliomas 43
Georg Karpel-Massler and Marc-Eric Halatsch
Part 3 MicroRNAs in Treatment of Glioma 57
Chapter 4 MicroRNA and Glial Tumors:
Tiny Relation with Great Potential 59
Jiri Sana, Marian Hajduch and
Ondrej Slaby
Chapter 5 The Role of microRNAs in Gliomas
and Their Potential Applications
for Diagnosis and Treatment 75
Iris Lavon
Part 4 Inhibition of Invasion in Treatment of Glioma 89

Chapter 6 Molecular Targets:
Inhibition of Tumor Cell Invasion 91
Raquel Brandão Haga and Silvya Stuchi Maria-Engler
VI Contents

Part 5 Blood-Brain Barrier in Glioma Therapy 109
Chapter 7 Blood-Brain Barrier and Effectiveness
of Therapy Against Brain Tumors 111
Yadollah Omidi and Jaleh Barar
Part 6 Gene Therapy of Glioma 141
Chapter 8 Glioma-Parvovirus Interactions:
Molecular Insights and Therapeutic Potential 143
Jon Gil-Ranedo, Marina Mendiburu-Eliçabe,
Marta Izquierdo and José M. Almendral
Chapter 9 The Potential and Challenges of siRNA-Based Targeted
Therapy for Treatment of Patients with Glioblastoma 161
M. Verreault, S. Yip, B. Toyota and M.B. Bally
Chapter 10 Hypoxia Responsive Vectors
Targeting Astrocytes in Glioma 199
Manas R. Biswal, Howard M. Prentice
and Janet C. Blanks
Part 7 LGI1 in Treatment of Glioma 217
Chapter 11 The Tumor Suppressor Function of LGI1 219
Nadia Gabellini
Part 8 Antioxidant Adaptive Response in Glioma 245
Chapter 12 Antioxidant Adaptive Response of Malignant
Glioma Related to Resistance to Antitumor Treatment 247
Tomohiro Sawa and Takaaki Akaike
Part 9 TRP Channels in Glioma Therapy 263
Chapter 13 Ionic Channels in the Therapy of Malignant Glioma 265

Xia Ding, Hua He, Yicheng Lu and Yizheng Wang









Preface

Brain, the source of human’s ingenuity, passion, motivation and emotions holds a
world of mystery and promises for scientists, biologists, physicians, philosophers and
poets! It is, therefore, not surprising that Gliomas, as the most common form of the
malignant brain tumors, impose such a strong impact on our society at different levels.
Despite a series of significant improvements in our understanding about the molecular
etiology of Gliomas, the road lays long in front of us to reach the ultimate goal of
elimination of the burden delivered to human health by these deadly diseases. But, in
this mix, there are also good news: First, the rate of malignant brain tumors in men
seems to be declining. Secondly, the overall incidence rate of Glioblastomas has been
stable suggesting that external risk factors may not influence the origination of these
malignancies
*
.
Novel Therapeutic Concepts for Targeting Glioma offers a comprehensive collection of
current information and the upcoming possibilities for designing new therapies for
Glioma by an array of experts ranging from Cell Biologists to Oncologists and
Neurosurgeons. A variety of topics cover therapeutic strategies based on Cell
Signaling, Gene Therapy, Drug Therapy and Surgical methods providing the reader

with a unique opportunity to expand and advance his knowledge of the field.
We remain grateful to the efforts of our colleagues at INTECH for providing such an
accessible and efficient platform for dissemination of science. Our hopes are raised and
our spirits are lifted because of endeavors of the people who not only seek but one day
will deliver human race’s freedom from Cancer.

Faris Farassati, PhD, PharmD,
Department of Medicine-Molecular Medicine Laboratory
The University Of Kansas Medical Center, Kansas City, Kansas,
USA

*
Kohler BA, Ward E, McCarthy BJ, Schymura MJ, Ries LAG, Eheman C, Jemal A, Anderson RA, Ajani
UA, Edwards BK. Report to the Nation on the Status of Cancer, 1975-2007, Featuring Tumors of the
Brain and Other Nervous System. JNCI; May 4, 2011.


Part 1
Surgical Therapy of Glioma