Pediatric emergency medicine trisk 4541 4541
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Clinical condition Treatment
Postexposure prophylaxis
Inhalational
anthrax
Prophylaxis for 60 days c :
Ciprofloxacin 10–15 mg/kg
PO q12h OR
Levofloxacin 8 mg/kg PO
q12h OR
Doxycycline 2.2 mg/kg PO
q12h
Pneumonic plague
d
Ricin
Tularemia
(pneumonic)
Smallpox
Ciprofloxacin 10–15 mg/kg
IV q12h OR
Levofloxacin 8 mg/kg PO
q12h OR
Doxycycline 2.2 mg/kg IV
q12h
AND
Clindamycin a 10–15 mg/kg
IV q8h
AND
Penicillin G b 400–600k
U/kg/d IV ÷ q4h
AND consider:
Raxibacumab
(>50 kg: 40 mg/kg IV; 15–
50 kg: 60 mg/kg IV; <15
kg: 80 mg/kg IV) OR
Obiltoxaximab
(>40 kg: 16 mg/kg IV)
Gentamicin 2.5 mg/kg IV
q8h OR
Doxycycline 2.2 mg/kg IV
q12h OR
Ciprofloxacin 15 mg/kg IV
q12h OR
Levofloxacin 8 mg/kg
IV/PO q12h
Supportive therapy
Same as for Plague e
Doxycycline 2.2 mg/kg PO
q12h OR Ciprofloxacin
20 mg/kg PO q12h OR
Levofloxacin 8 mg/kg PO
q12h
Supportive therapy
Same as for Plague e
Tecoviramat 200 mg PO
Vaccination may be
q12h (for children 13–25
effective if given within
kg); 400 mg PO q12h (for
96 hours after exposure
children 25–40 kg); 600
