Pediatric emergency medicine trisk 2372 2372
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e-TABLE 94.10
TREATMENT INDICATIONS FOR NONTYPHI SALMONELLA
Scenario
Management
Asymptomatic carriage
None
Gastroenteritis, uncomplicated None needed, unless patients are at risk for
complications: <3 mo of age, HIV-infected,
functionally or anatomically asplenic,
immunosuppressed or
immunocompromised, or in presence of
chronic GI tract disease
Treatment options: ampicillin, TMP-SMX
based on local susceptibilities; azithromycin
or fluoroquinolones in regions where
resistance to penicillins and TMP-SMX is
common
Localized invasive disease
(meningitis, osteomyelitis,
abscess) in HIV-infected
children
Bacteremia, sepsis
Empiric ceftriaxone, then either ampicillin or
ceftriaxone for 4–6 wks
Empiric ceftriaxone, then change to oral
regimen (fluoroquinolone or azithromycin)
after patient becomes afebrile, for a total
course of therapy of 10–14 days
HIV, human immunodeficiency virus; GI, gastrointestinal; TMP-SMX, trimethoprim-sulfamethoxazole.
