Pediatric emergency medicine trisk 2412 2412
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Lymphadenopathy
CNS signs
Hemolytic anemia
CSF anomalies
Serologic
Certainty of
diagnosis
Definite
Probable
uniformly seen
Generalized nontender
adenopathy
Meningitis, meningismus,
seizures, cranial nerve
palsies, hydrocephalus,
pituitary dysfunction
Coombs negative, associated
with cryoglobulinemia.
Other hematologic findings:
thrombocytopenia,
leukopenia, or leukocytosis
Seen in approximately 20%:
CSF pleocytosis or elevated
CSF protein
1. Reactive (nontreponemal)
RPR (serum), VDRL (CSF)
serologic tests for syphilis FTA-ABS, TP-PA, or MHA2. Reactive treponemal test
TP
3. Reactive serologic test for
syphilis that does not revert
to nonreactive within 4 mo
4. Rising titer over 3 mo
Absolute clinical criterion
Any of the following:
• Serologic criteria three or
four
• One major criterion and
serologic criterion one or
two
• Two or more minor clinical
criteria and serologic
criterion one or two
• One major and one minor
clinical criterion
