Pediatric emergency medicine trisk 2404 2404
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Adverse effect
Drug(s)
Dermatitis
Abacavir, atovaquone, dapsone, delavirdine, efavirenz,
enfuvirtide (nodules at injection site), maraviroc,
nevirapine, primaquine, pyrimethamine, raltegravir,
ribavirin, sulfadiazine, trimethoprim-sulfamethoxazole,
voriconazole
Diarrhea
Atovaquone, didanosine, clindamycin, isoniazid
(suspension form only, which is sorbitol based),
nelfinavir, ritonavir, lopinavir/ritonavir, tenofovir
Hepatotoxicity
Atovaquone, azithromycin, clarithromycin, darunavir,
fluconazole, isoniazid, itraconazole, ketoconazole,
pyrazinamide, rifabutin, rifampin, rilpirivine,
trimethoprim-sulfamethoxazole, voriconazole, most
antiretrovirals; hepatic failure can be seen with
nevirapine. Tenofovir associated with severe lactic
acidosis.
Hypersensitivity
Abacavir, delavirdine, dolutegravir, etravirine, all protease
reaction
inhibitors (atazanavir, darunavir, fosamprenavir,
indinavir, lopinavir, nelfinavir, ritonavir, saquinavir,
tipranavir), rilpiridine
Lipodystrophy
All protease inhibitors (atazanavir, darunavir,
fosamprenavir, indinavir, lopinavir, nelfinavir, ritonavir,
saquinavir, tipranavir), delavirdine, etravirine,
rilpirivine
Musculoskeletal
All integrase strand transfer inhibitors (dolutegravir,
pain
enfuvirtide, raltegravir), tenofovir
Myelosuppression Amphotericin B, cidofovir, dapsone, enfuvirtide,
foscarnet, flucytosine, ganciclovir, hydroxyurea,
interferon alpha, linezolid, peginterferon-alpha
pyrimethamine, rifabutin, ribavirin, sulfadiazine,
trimethoprim-sulfamethoxazole, trimetrexate,
valganciclovir, zidovudine
Nephrotoxicity
Neuropathy
Acyclovir, adefovir, amphotericin B, cidofovir, foscarnet,
indinavir, pentamidine, tenofovir
Didanosine, isoniazid, linezolid, stavudine, zalcitabine
