Andersons pediatric cardiology 1690
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Cardio-oncology
ThomasD.Ryan
Abstract
Overthepastseveraldecadestherehavebeensignificantimprovementsin
thecareofpatientsdiagnosedwithcancer.Oneunintendedconsequenceof
thesuccessesoftherapyisagrowingpopulationofpatientsatriskfor
cancertreatment–relatedcardiotoxicity(CTC).Manychemotherapeutic
agentsleadtoawidevarietyofcardiovascularpathologiesthatcan
manifestwithinhoursofadministrationordecadeslater.Survivorsarefive
tosixtimesmorelikelythansiblingcontrolstodevelopcardiovascular
diseaseofvariousetiologies,includingsymptomaticheartfailure,
asymptomaticventriculardysfunction,valvardisease,coronarydisease,
arrhythmias,autonomicdysfunction,vascularchanges,andpericardial
disease.Thefieldofcardio-oncologyisfocusedonprevention,
surveillance,andtreatmentofCTC.
Keywords
Cardio-oncology;cardiomyopathy;heartfailure;oncology;cancer;
anthracycline;chemotherapy;radiationtherapy
