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disease. However, these children are usually not well appearing. Needle aspirates from the center of the cellulitic
region are positive in between 5% and 40% of cases, with punch biopsies having a higher culture yield. Bedside
ultrasound may allow the clinician to differentiate abscesses from cellulitis. Treatment should be directed at S.
aureus and GAS, with empiric selection guided by the local prevalence of MRSA and past cultures. While most
children with cellulitis can be managed in the outpatient setting, initial parenteral therapy should be considered in
the following cases: immunocompromised; toxic-appearance; rapidly progressive lesions; facial or circumferential
involvement; crepitance or violaceous skin discoloration; or pain out of proportion to examination. The latter two
findings should prompt evaluation for necrotizing fasciitis and immediate surgical consultation. Standard
precautions should be used unless draining lesions exist, in which case contact precautions should be implemented.
Mastitis, Neonatal
Mastitis is an infection of breast tissue; in neonates, it is most commonly seen in the first 3 weeks of life and is
more common in girls and in term infants. The most common etiology is S. aureus, but GBS, E. coli, and
Salmonella can also cause neonatal mastitis. Infants present with unilateral painful erythema and induration of the
breast bud. Fever may be absent even in bacteremic children. Blood cultures usually are negative; cultures of
purulent drainage often are positive. Empiric antibiotic coverage should include nafcillin (for coverage of GAS,
GBS) and gentamicin and vancomycin if the child lives in an area with high MRSA prevalence. Incision and
drainage is advisable in the case of local fluctuance, with careful attention to avoiding injury to the developing
breast bud, which is already at risk of damage from the infectious process and may lead to cosmetic issues of the
breast first noted at adolescence. Standard precautions should be used unless draining lesions exist, in which case
contact precautions should be implemented.
Omphalitis
Omphalitis is an infection of the umbilical stump and surrounding tissues. The most common pathogens are S.
aureus and GAS; GBS (Streptococcus agalactiae ) and gram-negative enterics can also cause omphalitis. The
incidence has decreased in industrialized countries because of triple dye placed on the stump immediately after
delivery; omphalitis usually is seen in the first 14 days of life. It is more common in premature infants and in
infants with complicated deliveries. The first symptoms are purulent, foul-smelling drainage and later erythema
around the stump (ultimately, many children have erythema that completely encircles the stump). Later
manifestations include lethargy, fever or hypothermia, and irritability; late examination findings include erythema
and induration of the anterior abdominal wall. Minimal drainage or noncircumferential erythema is not sufficient