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Andersons pediatric cardiology 1380

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OtherTreatments
Asmentionedpreviously,rhabdomyomashavebeenshowntorespondto
therapywithmTORinhibitors,andvasculartumorsininfantsmaybetreated
withantiangiogenictherapy,suchascorticosteroidsorinterferon-α.99,112Very
littledataareavailableonchemotherapyorradiationinchildrenwithcardiac
sarcomas.Thesetherapiesgenerallydonotappearefficacious.1,130


AnnotatedReferences
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PediatrCardiol.2004;25(3):252–273.
Thismeta-analysisoffersahighlydetailedand
comprehensiveoverviewoffetalandneonatal
cardiactumors,compilingdatafrom224fetuses,
stillborns,andneonates..
ShiL,WuL,FangH,etal.Identificationand
clinicalcourseof166pediatriccardiactumors.
EurJPediatr.2017;176(2):253–260.
Largemulticenterexperienceof158patientswith
primarycardiactumorsdiagnosedatfour
Chinesehospitalsover16years,with
descriptionsofpresentingsymptomsandclinical
manifestations,aswellassurgicaloutcomesin
49patientswithbenignprimarytumors..
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Cardiactumorsandassociatedarrhythmiasin
pediatricpatients,withobservationsonsurgical
therapyforventriculartachycardia.JAmColl
Cardiol.2011;58(18):1903–1909.
Largesingle-centerexperienceof173patients
compiledover42years.Althoughtheemphasis


isonarrhythmogenicburdenoftumorsand
responsetomedicalandsurgicalmanagement,


thereisimportantinsightintotheoverall
incidenceoftumors,presentingsignsand
symptoms,andsurgicalresultsforall
indications..
PadalinoMA,VidaVL,BoccuzzoG,etal.Surgery
forprimarycardiactumorsinchildrenearlyand
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heartsurgeonsassociationstudy.Circulation.
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Largemulticenteranalysisofsurgicalindications
andresultsin89primarycardiactumorcases,
withanoverallearlyandlatemortalityrateof
4.5%forallpatients.Ifonlybenigntumorswere
considered,earlymortalitydecreasedto2.4%..
LinnemeierL,BenneyworthBD,TurrentineM,
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a45-year,single-institutionreview.WorldJ
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45years.Inthisseriesthemortalityfor
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in154patientswithtuberoussclerosiscomplex.
Pediatrics.2006;118(4):e1146–e1151.

Rhabdomyomasarethemostcommonprimary



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