Pediatric emergency medicine trisk 1365 1365
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palmoplantar keratoderma. There are often characteristic islands of sparing (
Fig. 70.8 ). It is most often confused with psoriasis, which it can closely
resemble, but PRP lesions lack the overlying silvery scale of psoriasis.
PRP is often idiopathic and sporadic in its occurrence. PRP can occur as a
postinfectious process (most commonly streptococcal and occasionally
HIV), as an adverse drug reaction, and in adults, as a paraneoplastic
phenomenon associated with a variety of malignancies. The condition has
also been associated with CARD mutations and autosomal dominant
inheritance (early-onset form).
Long-term treatments include use of emollients, topical corticosteroids,
topical retinoids, vitamin D analogs, topical calcineurin inhibitors, and
systemic agents such as phototherapy and biologic agents (infliximab,
ustekinumab, etanercept, adalimumab).
