Hypocalcemia
Cramps, carpopedal
(hypoparathyroidism)
spasms,
paresthesias,
lethargy, apathy,
convulsions,
hypotension
Diabetes insipidus
Plasma calcium,
phosphate, alkaline
phosphatase
10% calcium
gluconate 1
mL/kg IV over
15 min
Polyuria, polydipsia, Paired plasma and urine Central : IV fluids
dehydration,
osmolality and
at two-thirds
irritability, fever,
sodium
maintenance rate
drowsiness, coma
plus replete
deficit over 48
hrs; vasopressin
1–10 mU/kg/hr
IV
Nephrogenic : IV
fluids at urine
output plus
replete deficit
over 48 hrs
Syndrome of
Anorexia, headache, Paired plasma and urine Seizures : 3%
inappropriate
nausea, vomiting,
osmolality and
saline at 1–3
antidiuretic hormone
irritability,
sodium
mL/kg IV;
secretion
seizures, coma
furosemide 1
mg/kg IV stat;
benzodiazepines
Otherwise : fluid
restriction
Thyroid storm
Goiter,
Free T4 , Total T3, TSH Propranolol 10
exophthalmos,
μg/kg IV over
high fever,
15 min; Lugol
tachycardia,
iodine 9–15
congestive cardiac
drops/day
failure, delirium,
orally;
stupor
methimazole
20–30 mg q6–
12h (initially);
tepid sponging
Neonatal thyrotoxicosis Goiter, failure to
Free T4 , Total T3, TSH Propranolol 1
gain weight,
mg/kg tid orally;
irritability,
potassium
tachycardia,
iodide two drops
congestive cardiac
bid orally;
failure
methimazole