Andersons pediatric cardiology 266
Bạn đang xem bản rút gọn của tài liệu. Xem và tải ngay bản đầy đủ của tài liệu tại đây (153.72 KB, 3 trang )
FIG.11.4 (A)Kaplan-Meiercurveforacohortofsubjectswithcongenital
heartdiseasewhounderwentnewbornsurgery,demonstratingsurvival
probabilityoutto70months.Notethesignificantlylowersurvivaloutcome
forthosewithimpairedmaternal-fetalenvironment.(B)Kaplan-Meiercurve
foracohortofsubjectswithhypoplasticleftheartsyndrome(HLHS)who
underwentnewbornsurgery,demonstratingsurvivalprobabilityoutto70
months.Notetheimpactofanimpairedmaternal-fetalenvironmenton
surgicalsurvivaloutcome.(FromGaynorJW,ParryS,MoldenhauerJS,et
al.Theimpactofthematernal-fetalenvironmentonoutcomesofsurgery
forcongenitalheartdiseaseinneonates.EurJCardiothoracSurg.
2018;54[2]:348–353.)
AnnotatedReferences
BarkerDJP,ThornburgKL.Placental
programmingofchronicdiseases,cancerand
lifespan:areview.Placenta.2013;34(10):841–
845.
Morphologicvariationsinnormalplacental
developmentcanpredictawiderangeofadultonsetdiseases,thoughttobedueto
programmingthatlaterincreasesriskfor
diseasesrangingfromcoronaryarterydiseaseto
colorectalcancer..
BoydHA,BasitS,BehrensI,etal.Association
betweenfetalcongenitalheartdefectsand
maternalriskofhypertensivedisordersof
pregnancyinthesamepregnancyandacross
pregnancies.Circulation.2017;135(19).
Pregnanciesaffectedbyfetalcongenitalheart
diseaseareassociatedwithearlypreeclampsia
inthesamepregnancyaswellasinsubsequent
pregnanciesunaffectedbyfetalCHD,suggesting
amaternaletiologyforbothprocesses,suchas
angiogenicimbalance..
GaynorJW,ParryS,MoldenhauerJS,etal.The
impactofthematernal-foetalenvironmenton
outcomesofsurgeryforcongenitalheartdisease
inneonates.EurJCardiothoracSurg.
2018;54(2):348–353.
Impairedmaternal-fetalenvironment,asindicated
bypreeclampsia,pretermbirthorinfantswho
aresmallforgestationalage,iscommonin
congenitalheartdiseaseandassociatedwith
decreasedpostoperativesurvivalat3years..
MatthiesenNB,HenriksenTB,AgergaardP,etal.
Congenitalheartdefectsandindicesofplacental
andfetalgrowthinanationwidestudyof924
422liveborninfants.Circulation.
2016;134(20):1546–1556.
Placentalweightisassociatedwithmeasuresof
overallgrowthandcerebralgrowthinfetuses
withCHD..
RychikJ,GoffD,McKayE,etal.Characterization
oftheplacentainthenewbornwithcongenital
heartdisease:distinctionsbasedontypeof
cardiacmalformation.PediatrCardiol.2018.
Placentasofneonateswithcongenitalheart
diseasearedisproportionallysmallerthan
normal,withincreasedincidenceofabnormal
capillaryproliferation,hypomaturevilli,
thrombusandinfarction..
